Dysbindin (DTNBP1) variants are associated with hallucinations in schizophrenia
نویسندگان
چکیده
منابع مشابه
Dysbindin (DTNBP1)--a role in psychotic depression?
Previous studies yielded evidence for dysbindin (DTNBP1) to impact the pathogenesis of schizophrenia on the one hand and affective disorders such as bipolar or major depressive disorder (MDD) on the other. Thus, in the present study we investigated whether DTNBP1 variation was associated with psychotic depression as a severe clinical manifestation of MDD possibly constituting an overlapping phe...
متن کاملRelationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia.
OBJECTIVE The purpose of this study was to determine whether a haplotype in the dystrobrevin binding protein 1 (DTNBP1) gene previously associated with schizophrenia not only increases the susceptibility to psychotic illness but also to a more or less clinically specific form of psychotic illness. METHOD In the Irish Study of High-Density Schizophrenia Families, subjects with psychotic illnes...
متن کاملAnalysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
DTNBP1 was first identified as a putative schizophrenia-susceptibility gene in Irish pedigrees, with a report of association to common genetic variation. Several replication studies have reported confirmation of an association to DTNBP1 in independent European samples; however, reported risk alleles and haplotypes appear to differ between studies, and comparison among studies has been confounde...
متن کاملDTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias.
Dysbindin (DTNBP1) is a recently characterized protein that seems to be involved in the modulation of glutamatergic neurotransmission in the human brain, thereby influencing prefrontal cortex function and associated cognitive processes. While association, neuroanatomical and cellular studies indicate that DTNBP1 might be one of several susceptibility genes for schizophrenia, the effect of dysbi...
متن کاملHuman dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain.
CONTEXT The schizophrenia-susceptibility gene dysbindin (DTNBP1 on 6p22.3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain. OBJECTIVES To determine whether brain regions implicated in schizophrenia express dysbindin and whether abnormal levels of dysbindin ...
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ژورنال
عنوان ژورنال: European Psychiatry
سال: 2015
ISSN: 0924-9338,1778-3585
DOI: 10.1016/j.eurpsy.2015.01.008